Common tools based on landmarks in medical image elastic registration are the thin plate spline (TPS). However

in real application

such scheme would deform the image globally when the deformation desired is local. Although radial basic functions can limit the effect of the deformation locally

how to choose its parameter is still a problem. This paper used Gaussian function to compute the local elastic registration

purposed a method to choose Gaussian parameter to localize the deformation between two landmarks. Using this method in local image elastic registration base on landmarks

deformation of image could be reduced. Finally

this paper provides lots of experiments to support our conclusion.