The studies on the morphometric atypism of the nuclear sections of adenomatoid hyperplasia of liver,normal liver cells and hypatocellular carcinoma

doi:10.11834/jig.19960482

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The studies on the morphometric atypism of the nuclear sections of adenomatoid hyperplasia of liver,normal liver cells and hypatocellular carcinoma
Vol. 1, Issue 4, Pages: 307(1996)
Published Online：20 March 2012，

Published：1996
DOI： 10.11834/jig.19960482
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DOI：

The studies on the morphometric atypism of the nuclear sections of adenomatoid hyperplasia of liver,normal liver cells and hypatocellular carcinoma[J]. Journal of Image and Graphics, 1996, 1(4): 307. DOI： 10.11834/jig.19960482.

摘要

应用数字图象分析系统，先测定肝腺癌样增生、正常肝细胞和肝癌细胞的７种细胞核截面形态参数，包括面积、周长、最大卡规径，最小卡规径，等面积圆直径、圆形指数和形状指数。结果显示肝腺瘤样增生和肝癌细胞的上述７种形态参数的平均值均极其明显异常于正常肝细胞（p<0.001）；肝腺瘤样增生的面积、等面积回直径、周长和圆形指数的平均值与肝癌细胞有明显差异（Ｐ＜Ｏ．０５），但这些差异互相交织难于用到临床，为此重新定义新参数奇异性并通过分解其为椭圆度和粗糙度解耦了原参数的交织关系，较准确地描述了三类细胞核的真正的形态特征。进一步的结果证实，这些新定义的参数比原参数具有更高的灵敏度，用这些新参数来分析其细胞核截面形态的奇异性，足以证实肝腺瘤样增生已不属正常肝细胞群体，接近某类肝癌细胞．但仍不属肝癌细胞群体，而是一类形态最不规则的异常肝细胞群体；进而导出了从细胞核截面的奇异程度区分这些细胞群体（包括肝癌细胞的两个子类）的定量标准，为肝腺瘤样增生和肝癌的病理学研究及其临床辅助诊断提供了一种新方法。

Abstract

Seven parameters concerning cellular nuclear sections

including area

perimeter

maximum feret diameter

minimum feret diameter

the equivalent-area circle diameter

circularity factor and shape factor

in adenomatoid hyperplasia of the liver (AHL)

normal liver cells (NLC) and hepatocellular carcinoma (HCC)

were first measured and analyzed quantitatively using the digital image analysis technology. The results showed: the average values of all the above seven parameters in AHL and HCC were very significantly different from those in NLC (p<0.01)

the average values of four parameters (area

perimeter

the equivalent-area circle diameter

circularity factor) in AHL were significantly different from those is HCC(p

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