We present an opimized method for multi-retinal image mosaicking.First

the feature-based hierachical

robust estimation method completes a pairwise registration. Then a method is proposed to achieve good registration

which is based on overlaping regions for registration correction. The graph is established by the elationship between the pairwise registrations. The geometric error and similarity are selected as the weight to find the shortest path and to decide the anchor image. The joint estimation is constructed by direct constraints from the anchor image and indirect constraints from non-anchor images. For image fusion

multi-band blending is proposed

which is based on distance transform. The stitching seam is removed and a brightness blending image is achieved. Experimental results show that the method can effectively eliminate the error accumulation

achieving a precise registration and a seamless mosaic for multi-retinal image independent of the input order.